Kudiwa kwemishonga
COVID-19 inokonzerwa nehutachiona neinoveli SARS-CoV-2 pathogen, iyo inobata uye inopinda maseru anotambira kuburikidza neiyo spike protein.Parizvino, kune anopfuura 138.3 miriyoni akanyorwa nyaya pasi rose, uye nhamba yevakafa iri kusvika mamirioni matatu.
Kunyangwe majekiseni akabvumidzwa kuti ashandiswe nechimbichimbi, kushanda kwawo kurwisa mamwe emhando itsva kwakapokana.Pamusoro pezvo, kuvharirwa kweinosvika makumi manomwe muzana ehuwandu munyika dzese dzepasi kungangotora nguva yakareba, tichitarisa nhanho iripo yekudzivirira, kushomeka kwekugadzirwa kwejekiseni, uye matambudziko ekugadzirisa.
Nyika icharamba ichida mishonga inoshanda uye yakachengeteka, nekudaro, kupindira mukurwara kwakakomba kunokonzerwa nehutachiona uhu.Ongororo yazvino inotarisana nemunhu uye synergistic chiitiko che curcumin uye nanostructures kurwisa hutachiona.

Kudiwa kwemishonga
COVID-19 inokonzerwa nehutachiona neinoveli SARS-CoV-2 pathogen, iyo inobata uye inopinda maseru anotambira kuburikidza neiyo spike protein.Parizvino, kune anopfuura 138.3 miriyoni akanyorwa nyaya pasi rose, uye nhamba yevakafa iri kusvika mamirioni matatu.
Kunyangwe majekiseni akabvumidzwa kuti ashandiswe nechimbichimbi, kushanda kwawo kurwisa mamwe emhando itsva kwakapokana.Pamusoro pezvo, kuvharirwa kweinosvika makumi manomwe muzana ehuwandu munyika dzese dzepasi kungangotora nguva yakareba, tichitarisa nhanho iripo yekudzivirira, kushomeka kwekugadzirwa kwejekiseni, uye matambudziko ekugadzirisa.
Nyika icharamba ichida mishonga inoshanda uye yakachengeteka, nekudaro, kupindira mukurwara kwakakomba kunokonzerwa nehutachiona uhu.Ongororo yazvino inotarisana nemunhu uye synergistic chiitiko che curcumin uye nanostructures kurwisa hutachiona.

Curcumin
Curcumin inhengo yepolyphenolic yakaparadzaniswa kubva kune rhizome yechirimwa cheturmeric, Curcuma longa.Inogadzira iyo huru curcuminoid muchirimwa ichi, pa77% yehuwandu, nepo diki komputa curcumin II inogadzira 17%, uye curcumin III inosanganisira 3%.
Curcumin yakave yakaratidza uye yakanyatso dzidza, seyakasikwa molecule ine mishonga yemishonga.Kushivirira kwayo uye kuchengetedzeka kwakanyatso kunyorwa, ine huwandu hwepamusoro hwe12 g / zuva.
Kushandiswa kwaro kwakatsanangurwa se anti-inflammatory, anticancer, uye antioxidant, pamwe chete nehutachiona.Curcumin yakataurwa semorekuru ine mukana wekuporesa pulmonary edema uye mamwe maitiro anokuvadza anotungamira kumapapu fibrosis anotevera COVID-19.

Curcumin inhibits viral enzymes
Izvi zvinofungidzirwa kuve nekuda kwekugona kwayo kuvharidzira hutachiona pachahwo, pamwe nekugadzirisa nzira dzekuzvimba.Inogadzirisa kunyorwa kwevhairasi uye mutemo, inosunga nepamusoro potency kune viral main protease (Mpro) enzyme iyo inokosha pakudzokorora uye inodzivisa kusungirirwa kwehutachiwana uye kupinda musero rinogamuchira.Inogonawo kukanganisa mavhairasi maitiro.
Huwandu hwayo hwezvinangwa zveantiviral zvinosanganisira hutachiona hwehepatitis C, hutachiona hwehutachiona hwehutachiona (HIV), hutachiona hweEpstein-Barr uye hutachiona hwefuruwenza A.Izvo zvinonzi inhibisa iyo 3C-senge protease (3CLpro) zvakanyanya kupfuura zvimwe zvigadzirwa zvakasikwa, zvinosanganisira quercetin, kana zvinodhaka senge chloroquine uye hydroxychloroquine.
Izvi zvinogona kubvumira kuderedzwa kwehutachiwana mukati mesero remunhu zvakanyanya kukurumidza kupfuura mamwe madhiragi asingadziviriri, uye nokudaro kudzivirira kufambira mberi kwechirwere kune acute respiratory distress syndrome (ARDS).
Inodzivisawo papain-like protease (PLpro) ine 50% inhibitory concentration (IC50) ye5.7 µM inodarika quercetin nezvimwe zvinhu zvakasikwa.

Curcumin inhibits host cell receptor
Hutachiona hunonamira kumunhu anotambira sero receptor, iyo angiotensin-inoshandura enzyme 2 (ACE2).Zvidzidzo zvekuenzanisira zvakaratidza kuti curcumin inhibits kusangana kwehutachiona-receptor munzira mbiri, nekuvharisa ese ari maviri spike protein uye ACE2 receptor.
Nekudaro, curcumin ine yakaderera bioavailability, nekuti haina kunyungudika zvakanaka mumvura uye haina kugadzikana mune aqueous media, kunyanya pa pH yakakwirira.Kana ikabatwa nemuromo, inopinda nekukurumidza metabolism neura uye chiropa.Ichi chipingamupinyi chinogona kukundwa nekushandisa nanosystems.
Mazhinji akasiyana nanostructured carriers anogona kushandiswa kune chinangwa ichi, senge nanoemulsions, microemulsions, nanogels, micelles, nanoparticles uye liposomes.Vatakuri vakadaro vanodzivirira kuparara kwemetabolism ye curcumin, inowedzera kunyungudika kwayo uye kuibatsira kufamba nepakati pebiological membranes.
Zvitatu kana kupfuura nanostructure-based curcumin zvigadzirwa zvatove kutengeswa, asi zvidzidzo zvishoma zvakaongorora kushanda kwavo kurwisa COVID-19 mu vivo.Izvi zvakaratidza kugona kwemagadzirirwo ekugadzirisa mhinduro dzemuviri uye kuderedza zviratidzo zvechirwere, uye pamwe nekukasika kupora.